Comparative genomic analyses highlight the contribution of pseudogenized protein-coding genes to human lincRNAs
Abstract Background The regulatory roles of long intergenic noncoding RNAs (lincRNAs) in humans have been revealed through the use of advanced sequencing technology.Recently, three possible scenarios of lincRNA origins have been proposed: de novo origination from intergenic regions, duplication from other long noncoding RNAs, and pseudogenization f